Gene expression, DNA damage, DNA structure and DNA-binding proteins structures, super-resolution (SMLM, RIM, SIM, Airyscan), single particle tracking, photo-manipulation, Correlative Light Electron Microscopy (CLEM)

Resolved fluorescence acquisition combining a supercontinuum pulsed laser and wide-field detection (time-gated), with the possibility of TIRF/hilo-type optical sectioning. This device allows the observation of biosensors and/or the monitoring of interactions, and can be used in particular in the observation of the Flipper-Tr probe to provide information on local stresses.

STORM/DNA-PAINT acquisition for in-depth and/or complex environment observation, with uniform precision thanks to axial position encoding in structured illumination.

The offer focuses on resolving molecular interactions within living cells by combining advanced quantitative microscopy methods. Techniques such as FLIM, FCS, FRAP, SPT, and super-resolution imaging enable precise analysis of interaction dynamics, diffusion, and nanoscale organization. This integrated approach provides high spatial and temporal resolution for studying biomolecular processes in their native environment.

The offer provides state-of-the-art instruments optimized for the detailed characterization of upconversion nanoparticles (UCNPs). These systems enable the study of their photophysics and stability, as well as their application in bioimaging. Particular emphasis is placed on long-term single-particle tracking in living cells under near-infrared excitation..

The Imaging Facility at IBMP-CNRS can help researchers design, adapt, build or automate original pieces of laboratory equipment in the field of biological imaging.

The Imaging Facility at IBMP-CNRS provides researchers with access to state-of-the-art microscopy techniques, including fluorescence, confocal, and 3D scanning electron microscopy. The platform supports a variety of sample preparation workflows, such as live-cell imaging and cryotechniques, and offers guidance at every step, from experimental design to image data analysis. Services are available for projects on plant tissues, microbial systems, and cell cultures, enabling users to visualize structures and processes at high resolution. The facility is dedicated to making advanced imaging approaches accessible, fostering collaboration, and helping researchers obtain reliable, quantitative results.