Multimodal microscopy, by combining fluorescence, harmonic and electron microscopy signals, is therefore of real interest for taking advantage of complementary information and increasing the sensitivity of pathology detection to qualify a complex tissue state.
Ex: Imaging of stimulated Raman scattering (SRS), coherent anti-Stokes Raman scattering (CARS), and two-photon (2P) fluorescence (or autofluorescence). We will thus be able to offer multimodal analysis on a single sample section in order to obtain spatial mapping of molecular compounds of interest, such as CH2 groups for lipid analysis (steatosis assessment) or CH3 for protein analysis.