RIM, based on natural laser speckle illumination, is a method of choice for super-resolved imaging of living cells in depth. The idea is to combine optically resolved laser speckle illumination with an algorithm that exploits the statistical invariance of speckle. A stack of hundreds of random speckle images is acquired using a random diffusive element, then deconvoluted to reconstruct the optical cross-section of the super-resolved image. The invariant properties of the statistics of the speckle scattering through the biological sample make it possible to obtain images in depth. In addition, the wide-field illumination and detection configuration ensures high acquisition speed and sample preservation.