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We’ve got many news and upcoming events to share with you! Here is a quick rundown.
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Combining AFM with SMLM to characterize nuclear pore complexes
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Nuclear pore complexes (NPCs) are the only gateways between the nucleus and cytoplasm in eukaryotic cells, facilitating the transport of selected cargoes of size from a few up to hundred nanometers. This versatility implies an important pore plasticity. Here, by combining atomic force microscopy (AFM) and single molecule localization microscopy (SMLM), a group led by France-BioImaging R&D team members Christine Doucet and Pierre Emmanuel Milhiet revealed that the NPC basket is very soft and explores a large conformational landscape: apart from its canonical basket shape, it dives into the central pore channel or opens, highlighting how this structure can adapt, and let morphologically diverse cargoes shuttle through NPCs.
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Studying Huntington's disease with correlative AFM-Fluorescence Microscopy
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Huntington’s disease is a neurodegenerative disorder caused by an extended polyglutamine (poly-Q) tract in huntingtin. Here, using NMR, the team of Pau Bernado (CBS Montpellier) demonstrated that this poly-Q tract adopts long α-helical conformations. By adding correlative Atomic Force Microscopy and Fluorescence Microscopy data obtained in the France-BioImaging facility PIBBS in Montpellier, they could demonstrate that the stability of this α-helix is a stronger signature than the number of glutamines, in defining the aggregation kinetics and the structure of the resulting fibrils, potentially linked to their pathogenicity.
Check the full article right here!
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Euro-BioImaging ERIC and EBRAINS are launching workshops in neuroscience and brain imaging!
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Euro-BioImaging ERIC and EBRAINS are launching a workshop series to provide an overview of the services provided by both Infrastructures, highlighting complementarities.
During the next one, on 27 October 2023 at 13:00-15:00 CEST, Euro-BioImaging ERIC will present the multiscale imaging capacity in the Neuroscience area. For this event, we are inviting Euro-BioImaging Nodes with expertise in the area of neuroscience and brain imaging to indicate their interest in delivering a short overview of their expertise and imaging services/technologies to the community and submit a short abstract for the presentation.
If you are interested, please submit your abstract by Sept 5th, 2023.
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France - Colombie: ECOS call for projects 2023 (all fields)
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The objective of the program is to strengthen the development of scientific research projects of excellence and to create networks of binational researchers with four of the countries of northern Latin America (Colombia, Mexico, Peru, Venezuela).
Submit your project online on the following platform: https://paris13.moveonfr.com/locallogin/643d5a1a90876837c9430404/eng &n…
Application deadline: June 15, 2023
For any request for information on this call for projects, you can contact the secretariat of the ECOS Nord committee at the following address: ecos.nord@univ-paris13.fr
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Looking for funding to cover your access? Here is an overview
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You are looking for funding to cover your access to France-BioImaging imaging facilities? Here you will find several funding and calls for projects currently open and specifically targeting access costs:
– France-BioImaging Access Fund (More information: https://france-bioimaging.org/how-to-cover-user-access-costs/)
– ISIDORe TNA Calls are still OPEN! Researchers interested in the following infectious diseases can apply for funding to access imaging technologies and services from Euro-BioImaging portfolio, including France-BioImaging facilities:
- Respiratory Pathogens: Zoonotic betaCoronaviruses, Influenza A, Y. pestis, M. tuberculosis / bovis, C. burnetii.
- Vector-borne pathogens and their vectors: Rift valley fever virus, Zika virus, Chikungunya virus, West Nile virus, Dengue virus, Japanese encephalitis virus, Yellow fever virus, Tick-borne encephalitis virus, Plasmodium, B. burgdorferi.
- Risk Group 4 Pathogens: Ebola virus, Marburg virus, Nipah virus, Hendra virus, Lassa virus, New World arenaviruses, CCHF virus.
- Other Pathogens with epidemic potential: Pathogen X, Orthopoxviruses, Non polio enteroviruses, Polio enteroviruses.
- We also remind you that the SARS-CoV-2, Covid-19 call is still open! (More information on ISIDORe website.)
Access to Euro-BioImaging services, please follow the Guidelines on the Euro-BioImaging website.
Unsure whether or not your work would be eligible? Contact the Euro-BioImaging Scientific Project Managers for advice: info@eurobioimaging.eu
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