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The Alsace node regroups 6 Life Sciences imaging facilities in Strasbourg, Illkirch and Mulhouse and six highly visible R&D teams expert in microscopy techniques and image analysis tools. The Alsace node offers a high level of technical and innovative methodological expertises in multi-scale imaging at the interface between biology, chemistry, optics and physics. The node aims to offer a fully integrated biological imaging portfolio from the molecule to the small animal/plant within the FBI infrastructure, based on its innovative chemical, optical and biocomputational developments, as well as on its already established network of state-of-the-art imaging instruments (super-resolution and quantitative fluorescence microscopies, confocal microscopies, F-techniques, small animal imaging systems (SPIM, macroscopes, OCT…)).
2022 in Numbers
- 336 hosted projects
- 90 publications
- 15 training programs
- 17 patents since 2011
Technological Innovations
- Tomographic diffractive microscopy (TDM) has been developed for 3D label-free imaging at cellular level, with an improved resolution compared to conventional microscopes, and, not being limited by possibly weak fluorescence, potentially at high speed (several 3D images/s).
- Single particle tracking and time-resolved luminescence microscopies have been developed to image upconverting nanoparticles (UCNPs). Due to their anti-Stokes emission, UCNPs allow imaging applications with exceptional signal to noise ratio.
- Single-shot full-field optical coherence tomography combines FF-OCT with off-axis interferometry. It extracts an FF-OCT image from a single interference acquisition, enabling single-shot high-resolution imaging within turbid media such as biomedical samples.
- Development of an integrated software for image reconstruction, correction, co-localization, resolution estimation, segmentation and clustering of labelled complexes (SharpViSu & ClusterViSu), including 3D analysis and segmentation of SMLM data using Voronoi diagrams.
- Molecular and supramolecular complexes have been developed for anti-Stokes imaging at the molecular level.
Tech transfer
- Single particle tracking and time-resolved luminescence microscopy of UCNPs
- Ultrabright lanthanide-based nanoparticles for diagnostic
- Plasma membrane probes (Membright) & Polarity-sensitive membrane probes (NR12S, NR12A, NR4A)
- Transmission Tomographic diffractive microscopy
- Integrated software for image reconstruction, correction, co-localization, resolution estimation, segmentation and clustering of labelled complexes (SharpViSu & ClusterViSu)
Most Innovative Systems Available for Booking
- Lightsheet microscope
- Super-Resolution (SMLM, STED)
- Electron Microscopy (Serial Block Face, Tomography, Cryo)
- Molecular Imaging (FCS, FLIM, anti-stokes)
- Live Imaging (Spinning disk)
Facility
QuESt (Quantum Efficiency Strasbourg)
Facility
Cellular Imaging platform – IBMP
Facility: Cellular Imaging platform – IBMP
Head: Jerome MUTTERER & Matthieu ERHARDT
jerome.mutterer@cnrs.fr & mathieu.erhardt@ibmp-cnrs.unistra.fr & ibmp-cnrs@unistra.fr
Plateforme d’Imagerie Cellulaire Institut de Biologie Moléculaire des Plantes 12, rue du Général Zimmer 67084 STRASBOURG Cedex
Services on this Facility
Service
Microscopy Technologies
Facility
In Vitro Imaging platform – INCI
Facility: In Vitro Imaging platform – INCI
Head: Sylvette CHASSEROT-GOLAZ (LM) & Frank PFRIEGER (EM)
chasserot@inci-cnrs.unistra.fr & Frank.Pfrieger@unistra.fr
8 Allée du Général Rouvillois, 67000 Strasbourg, France
Services on this Facility
Service
Microscopy Technologies
Facility
Imaging platform PI2 – I2CT
Facility: Imaging platform PI2 – I2CT
Head: Jean-Daniel FAUNY
jd.fauny@ibmc-cnrs.unistra.fr & pi2-microscopy@unistra.fr
Institut de Biologie Moléculaire et Cellulaire 2, Allée Konrad Roentgen - 67 084 Strasbourg Cedex - France
Services on this Facility
Service
Microscopy Technologies
Facility
PIC-STRA (Imaging platform at CRBS – STRAsbourg)
Facility: PIC-STRA (Imaging platform at CRBS – STRAsbourg)
Head: Pascal KESSLER
Pascal.Kessler@unistra.fr & crbs-picstra-ums38@unistra.fr
Centre de Recherche en Biomédecine de Strasbourg 1 rue Eugène Boeckel - CS 60026 - 67084 Strasbourg Cedex
Services on this Facility
Service
Microscopy Technologies
Facility
Confocal Microscopy platform – IS2M
R&D team
Microscopic Imaging & Image Treatment team – IRIMAS
R&D team
Synthesis for analysis (SynPA) team – IPHC
R&D team
Biophotonics of molecular and cellular interactions team – LBP
R&D team
Nanochemistry and Bioimaging team – LBP
R&D team
Photonic Instruments and Processes – ICube laboratory
R&D team
Large complexes involved in transcription and translation team – IGBMC
Key publications in 2022
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