The Rhone-Alpes node is composed of two core facilities: LyMIC in Lyon and ISdV in Grenoble. 
Gathered into one entity, LyMIC consists of three core facilities providing advanced photonic, atomic force and advanced electron microscopies.  ISDV comprises five photonic microscopy facilities and three electron microscopy experts. 
Six R&D teams complete the node and support the facility, located at Ecole Normale Supérieure de Lyon (ENS, Lyon) ; Grenoble Institute for Neuroscience (GIN, Grenoble) ; Institute for Advanced Biosciences (IAB, Grenoble) ; Institut Lumière Matière (ILM, Lyon) ; Laboratoire interdisciplinaire de Physique (LiPhy, Grenoble)

2023 in numbers

  • 412 hosted projects
  • 100 publications
  • 24 training programs
  • 5 patents since 2011

Technological Innovations

  • Adaptive Optics for Quantitative Confocal Microscopy (AOQCM)

 

  • Brillouin microscopy to map elastic forces

 

  • Adhesion forces measurements by RICM-microfluidic coupling (RICM, Reflection Interference Contrast Microscopy)

 

  • FastFLIM imaging integrated on TIRF microscopy

 

  • MERFISH / 3D Spatial transcriptomics

Tech transfer

  • Confobright aka Adaptive Optics for Quantitative Confocal Microscopy-AOQCM

 

 

  • Quantifret, a new calibration and analysis method allowing quantitative FRET imaging

 

  • SpheroRuler microbeads blinking in the far red channel in dSTORM buffer

Most innovative systems available for booking

  • AFM Nanowizzard IV with hybrid stage [to be delivered Dec 2024]
  • Confocal easy3D STED Abberior microscopes with adaptive optics, MATRIX detection and Timebow lifetime imaging
  • Nanoscope STEDYCON Abberior
  • Adaptive Optics for Quantitative Confocal Microscopy on a Nikon confocal microscope coupled with 2-photons imaging
  • Lightsheet microscopes – Blaze (Miltenyi Biotec) & LS7 (Zeiss)
  • Confocal Zeiss LSM 710 for molecular dynamics, equipped with Fast-FRAP and Fluorescence correlation spectroscopy (FCS) modules and 2-photons imaging 
  • Super-resolution microscope Safe360 from Abbelight mounted on an Olympus set-up
Facility

Lyon multiscale imaging center (LyMIC)

↗ Website ↗ Service + Info

Facility: Lyon multiscale imaging center (LyMIC)

Scientific Director: Pierre-François BREVET

pfbrevet@univ-lyon1.fr
Institute of Light and Matter, Rue Ada Byron, Villeurbanne, France

Services on this Facility

Service

Microscopy Technologies

Facility

Life Science Imaging – ISdV

↗ Website ↗ Service + Info

Facility: Life Science Imaging – ISdV

Scientific Director: Karine PERNET-GALLAY

karin.pernet-gallay@univ-grenoble-alpes.fr
Faculté de Médecine et Pharmacie - Université Grenoble Alpes, Avenue des Maquis du Grésivaudan, La Tronche, France

Services on this Facility

Service

Microscopy Technologies

R&D team

BioBrillouin team – Institut Lumière Matière

↗ Website + Info

R&D team: BioBrillouin team – Institut Lumière Matière

Team Leader: Thomas DEHOUX

thomas.dehoux@univ-lyon1.fr
10 Rue Ada Byron, Villeurbanne, France
R&D team

Optima team – Liphy

↗ Website + Info

R&D team: Optima team – Liphy

Team Leader: Aurélie DUPONT

aurelie.dupont@univ-grenoble-alpes.fr
140 Rue de la Physique, Saint-Martin-d'Hères, France
R&D team

MICROcell team – IAB

↗ Website + Info

R&D team: MICROcell team – IAB

Team leader: Olivier DESTAING

olivier.destaing@univ-grenoble-alpes.fr
5 Av. du Grand Sablon, 38700 La Tronche, France
R&D team

Seed Development team – RDP

↗ Website + Info

R&D team: Seed Development team – RDP

Team Leader: Gwyneth INGRAM

gwyneth.ingram@ens-lyon.fr
46 Allée d'Italie, Lyon, France
R&D team

3D electron microscopy team – GIN

↗ Website + Info

R&D team: 3D electron microscopy team – GIN

Team Leader: Karin PERNET-GALLAY

Karin.Pernet-Gallay@univ-grenoble-alpes.fr
Bâtiment Edmond J. Safra, 31 Chem. Fortuné Ferrini, 38700 La Tronche, France
R&D team

Spatial-Cell-ID EQUIPEX team – ENS

↗ Website + Info

R&D team: Spatial-Cell-ID EQUIPEX team – ENS

Team Leader: Jonathan ENRIQUEZ

jonathan.enriquez@ens-lyon.fr
ENS de Lyon - Institut de Génomique Fonctionnelle de Lyon (IGFL), 32-34 Avenue Tony Garnier, 69007 Lyon, France