PhD project – Synuclein diffusion analysis in neurons using event-based super-resolution microscopy
Organization: DNHS - Inserm U1195 / Université Paris-Saclay & Institut Langevin - ESPCI Paris / PSL University / CNRS
Position Information:
We are seeking a motivated candidate for a three-year PhD project funded by the European
COFUND programme LightInParis.
The objective is to study the mobility of alpha-synuclein in neurons in order to understand the molecular mechanisms underlying its aggregation in the context of neurodegenerative pathologies. The description of these mechanisms will rely on the use of event-based super-resolution microscopy.
The thesis is co-supervised by Christian Specht (DHNS, Inserm, Université Paris-Saclay, Le Kremlin-Bicêtre, France), Ignacio Izeddin and Clément Cabriel (Institut Langevin, ESPCI Paris, Université PSL, CNRS, Paris, France).
The starting date of the fellowship is the 1st October 2025.
Host institutes:
- DHNS (Inserm / Université Paris-Saclay), Le Kremlin-Bicêtre, France
- Institut Langevin (ESPCI Paris / PSL University / CNRS), Paris, France
More information about the offer:
- https://lightinparis.eu/synuclein-diffusion-analysis-in-neurons-using-event-based-super-resolution-microscopy-seven
- https://lightinparis.eu/wp-content/uploads/2025/01/COFUND_LightInParis_SPECHT.pdf
More information about our research activities:
- https://www.researchgate.net/profile/Christian-Specht
- https://www.institut-langevin.espci.fr/clement_cabriel?lang=en
- https://www.institut-langevin.espci.fr/ignacio_izeddin?lang=en
- https://dhns-inserm.fr/res_amyloidopathies/
Eligibility criteria: The applicant has to fulfil the MSCA-COFUND mobility rule stating that the
candidate must not have studied/worked in France for more than 12 months in the last 3 year (at
the starting date of the contract).
How to apply: Please send your CV and a motivation letter to christian.specht@inserm.fr,
clement.cabriel@espci.fr and ignacio.izeddin@espci.fr
Please feel free to contact us for more information about the fellowship.