A National Research Infrastructure for Biological Imaging

Postdoc position to study the Plasticity of the nuclear pore complex

Organization: Inserm, IUH Hôpital St Louis, Paris X, France

Position Information:

The NPC also emerged as a “hub” coordinating nuclear
transport, gene expression, chromatin organization and genome integrity. However
the limited number of NPC per cell imposes a certain “hierarchy” of these different
functions in time and space. We propose to focus on the nuclear side of the NPC and
precisely dissect how the “jeu de rôle” of post-translational modifications control the
NPC during the cell cycle as well as its function in the gene expression program at a
single cell level. This will be addressed in the model organism S. cerevisiae using a
combination of approaches including genetics, molecular biology, biochemistry and
live cell microscopy.