Research Engineer in Optical Instrumentation for the Development of In Vivo 3 Photon Microscopy
Organization: CIRCUITPHOTONICS In Vivo Imaging Platform
Position Information:
Context
CIRCUITPHOTONICS is a cutting-edge imaging platform dedicated to the functional exploration of neuronal circuits through in vivo imaging. It offers advanced technologies including 2- and 3-photon microscopy with photostimulation, high-speed 2-photon scanning, high-resolution photoacoustic imaging, and 2-photon endoscopy.
Located in Marseille, the platform operates jointly between INMED and INT, two institutes renowned for their expertise in neural activity imaging. It works closely with academic (Institut Fresnel, CENTURI) and industrial partners (Lightcore, DeepColor, Karthala, Bruker).
In this context, CIRCUITPHOTONICS and Bruker are seeking a highly motivated candidate to optimize the performance of the Ultima2P+ system, particularly by developing 3-photon microscopy applications for neuroscience.
Main missions
Instrument Optimization and Innovation
- Improve optical performance of 3-photon microscopy (signal, resolution, speed, imaging depth).
- Implement advanced techniques such as adaptive optics (AO) to correct for tissue-induced aberrations.
- Optimize group delay dispersion (GDD) to maximize multiphoton excitation efficiency.
- Integrate and calibrate new optical/electronic modules for faster, more reliable acquisition.
Maintenance and Technical Development
- Perform preventive and corrective maintenance of instrumentation.
- Develop diagnostic, calibration, and performance optimization protocols.
- Assist with installation and configuration of new scanning and detection technologies.
Scientific Collaboration and Training
- Work closely with neuroscientists to adapt systems to experimental needs (in vivo imaging, animal prep, neuronal indicators).
- Train advanced users on system operation and maintenance.
- The engineer will receive training at Bruker headquarters to gain full expertise with the Ultima2P+ system.
Documentation and Technology Watch
- Write technical protocols and performance reports (metrology).
- Keep up with advances in 2- and 3-photon microscopy, adaptive optics, and neuroscience instrumentation.
Profile
Education: Master’s degree or Engineering School (Bac+5) in applied physics, optics, photonics, or scientific instrumentation.
Experience: 2–5 years preferred in optical instrumentation; experience in advanced microscopy for biological or neuroscience applications is a strong plus.
Technicals skills:
- Expertise in multiphoton microscopy (2- and 3-photon).
- Proficiency in experimental and adaptive optics (lenses, deformable mirrors, scanners).
- Knowledge of GDD optimization.
- Skills in applied electronics (detectors, interfaces, acquisition systems).
- Programming for control/acquisition: Python, MATLAB, or equivalent.
- Strong communication skills in both French and English.
Personal qualities:
- Scientific rigor and attention to detail.
- Curiosity and creativity for proposing technical improvements.
- Ability to work in a multidisciplinary team.
General information
Practical information
Localisation : CIRCUITPHOTONICS In Vivo Imaging Platform, Marseille, France
Contract type : Fixed-term contract (26 months)
Contract start day : June 1st, 2026
Salary : Approx. €37k/year depending on experience
Supervisor : Scientific and Technical Director, Rosa Cossart
Benefits and Working Environment
- Access to a state-of-the-art in vivo neuroscience imaging platform.
- Participation in innovative projects and diverse scientific collaborations.
- Opportunities for continuous training and professional development.
- Possibility to contribute to scientific publications and presentations.
To Apply: Please send your application to: aurelie.picardo-carabalona@inserm.fr Applications should include: a detailed CV, a cover letter, and two letters of recommendation.
Application deadline: March 6th, 2026