France-BioImaging

A National Research Infrastructure for Biological Imaging

Scientist position in super-resolution microscopy at the Centre for Integrative Biology (Strasbourg, France)

Organization: Centre de Biologie Intégrative / IGBMC

Position Information:

We are seeking an enthusiastic scientist in super-resolution microscopy to join us at the Centre for Integrative Biology, IGBMC, Illkirch, France.

We have recently done a series of developments in super-resolution microscopy to facilitate single molecule localization microscopy (SMLM) analysis. This includes a pipeline for image reconstruction, drift correction, chromatic aberration correction for dual-color analysis and resolution estimation (Andronov et al., Bioinformatics 2016), Voronoi-diagram based tools for 2D clustering and segmentation analysis (Andronov et al., Sci Rep 2016) and most recently 3D clustering and segmentation analysis based on Voronoi diagrams (Andronov et al., Bioinformatics 2018).

The person to recruit should have a strong interest in conducting such developments, which aim at (i) routine implementation of SMLM for various projects at the institute and for external users as part of the National and European Infrastructures FRISBI and Instruct-ERIC, (ii) performing developments in correlative light and electron microscopy (CLEM) at the interface between imaging, FIB/SEM, cryo electron tomography and single particle cryo-EM. The long-term aim is to interface SMLM and cryo-EM to observe and reconstruct in 3D macromolecular complexes at high resolution once they have been localized and imaged in the cellular context.

 

The person to recruit (Engineer or PhD) should have a master or a PhD and have a strong background in imaging, optics, physics or informatics & software developments and ideally have experience in super-resolution microscopy (e.g. (d)STORM or PALM etc.).

 

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