Apply here before 11 November: https://emploi.cnrs.fr/Offres/CDD/UMR8227-BENCHA-001/Default.aspx?Lang=EN

Missions

A 3-year post-doctoral position is open in the team “Morphogenesis of Macroalgae (MMA)”, https://www.sb-roscoff.fr/en/team-morphogenesis-macroalgae-mma at the Station Biologique Roscoff (France) in the framework of the ERC-Adv project “ALTER e-GROW” (2023-2028).
The objective is to map in 3D the cellular parameters (cell shape, cell mechanics, intracellular organisation) during the formation of 3D tissues in the embryogenesis of brown algae.

Activities

Prepare algal material: culture, production of algal embryos, inoculation into microfluidic chips, marking of embryos (vital dyes and immunolocalisation), chemical treatments (osmotic shock, drugs, phytohormones), laser ablation
– Carry out cell imaging using light microscopy on live and fixed cells.
– Write articles

Skills

The candidate will have a PhD and preferably 2-7 years post-doctoral experience, with strong experience in confocal, two-photon and light-sheet imaging of living and fixed tissues. The candidate will be familiar with quantitative imaging approaches and analyses. He or she will preferably have experience with algae, plants, fungi or marine metazoans, and will be competent in managing their life cycle in the laboratory. He or she will have a background in developmental biology and an interest in tissue pattern genesis and mechanobiology. As the project requires technical developments, the candidate should have a high degree of autonomy, initiative and a strong taste for exploration and development of new methods, in addition to a great scientific curiosity.

Work Context

The “Morphogenesis of macroalgae” group focuses on understanding the morphogenesis of brown algae, with a strong appetite for mechanical modelling approaches, which are in turn hungry for quantitative cell biological data. Therefore, to feed the models, the team has recently developed functional imaging tools including time-lapse microscopy, microfluidics (doi: 10.3389/fmars.2021) and laser ablation (doi:10.3791/63518) to follow algal embryo development. All facilities for microscopy, image analysis and algal culture and manipulation will be available on site. For the past 15 years, Bénédicte Charrier has been betting on brown algae as unique organisms with an original evolutionary trajectory independent of plants and animals to identify new mechanisms of multicellular development. See doi.org/10.1371/journal.pbio.2005258, DOI: 10.1101/2021.08.28.458042,doi: 10.1016/j.cub.2019.09.021, doi:10.1105/tpc.110.081919.

The Institute:
The Biological Station (https://www.sb-roscoff.fr/en/) is based in the small port of Roscoff, in northern Brittany (Atlantic Ocean). It is located 20 km from the town of Morlaix, 60 km from the town of Brest and 3h30 from Paris by train. Founded in 1872, the Roscoff Biological Station (SBR) is a research and higher education centre for marine biology and ecology. It is jointly managed by the Centre national de la recherche scientifique (CNRS) and the Sorbonne University (Paris).

Additional Information

This contract is part of the ERC-Advanced project “ALTER e-GROW: Strategies of 3-D growth in brown algae” funded by the European Research Council.

Mission/Activities :

The unit of technology and services Photonic BioImaging (UtechS PBI directed by S. Shorte and N. Aulner) is an imaging facility dedicated to the study of infectious, systemic and tumoral diseases. The platform activities encompass imaging consulting, user training as well as multidisciplinary and collaborative research and development activities. The facility has a wide range of state-of-the-art microscope systems suited to adapt to most needs of the scientific community within the Institut Pasteur and beyond. They are maintained by a team comprising seven specialist engineers dedicated to user interaction and quality insurance.

The Imaging and Modeling unit directed by C. Zimmer has developed an open-source 3D super resolution technique based on single molecule localization microscopy (SMLM) method that allows exploring fixed samples at high tissue depth enabled by key optical elements located in the detection path. This technique improves conventional resolution by an order of magnitude in all directions and has already produced encouraging results. Financial support from Region Ile de France (program DIM ELICIT) has opened the opportunity to provision access through the UtechS-PBI, requiring the reliability of the system be demonstrated through meticulous characterization and performance assessment in an ISO 9001 environment. As part of this technological implementation the UtechS PBI team are seeking to recruit another research engineer expedite the work program under the supervision of the Instrumentation R&D lead engineer (E.Esposito). The successful candidate will assure the following activities:

  • Characterization of the SMLM based super-resolution optical system performance in 3 dimensions (X,Y,Z) depending on specific optical elements introduced.
  • Measurement of instrument drift during experimental condition
  • Ensure measurement repeatability and instrument reliability in ISO 9001 certified environment.
  • Redact an acquisition procedure to be used by PBI users wishing to benefit from such a system

 

Profile :

We are looking for a highly motivated Master level Biomedical engineer with interest in Optical instrumentation and physical measurement seeking a first experience in an exciting multidisciplinary environment. The successful candidate would show interest in open source technology and a hands-on approach to problem solving.

Skills required:

  • Good knowledge of biomedical instrument, in particular microscope systems
  • Rigorous in instrumental measurement taking and result presentation
  • Good oral and written skills
  • Fluent written and spoken English essential; basic French highly desirable
  • Team player
  • Computing development skills (Python/Java) would be a strong plus.

 

 

Contract type : Contrat à Durée Déterminée. Fixed contract

Contract duration : 12 month

Working hours: Full-Time

Week-end duties: No

Emergency duties: No

Travelling duties: No

 

Criteres Candidat

Experience level required : 0  to 2 years

Study Level required : BAC + 5 (Master Level)

Specific required certiffication or habilitation: None

Language Skills :                             English  (B2-Operational)

French (B2 Operational)

Position localisation : Paris, France

 

Availability :

Position available as of 1/03/2022

 

To apply : INSTITUT PASTEUR – Ingénieur de recherche – CDD 12 mois H/F

Missions

In the framework of the ERC Synergy ENSEMBLE contract, the mission of the post-doctoral fellow will be to use different imaging strategies to explore the brain extracellular space, in order to quantify and map this brain compartment, to identify key membrane actors in the understanding of this compartment.

Activities

The agent will use neuronal tissues (in vitro and ex vivo) with super-resolution imaging approaches

Skills

Imagerie de fluorescence, biologie cellulaire

Fluorescence imaging, cell biology

Work Context

Created on January 1, 2011, the Interdisciplinary Institute of Neuroscience (IINS) is a joint research unit attached to the CNRS and the University of Bordeaux.
With 160 people in 14 teams, IINS combines multidisciplinary skills to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As a component of Bordeaux Neurocampus, IINS is one of the major actors of the neuroscience community in Aquitaine.
The team studies the organization of transmembrane receptors on the surface of neuronal and glial cells in order to decipher the pathological mechanisms underlying neuropsychiatric disorders.

Constraints and risks

Monday to Friday, possibility of working shifts

Application Deadline : 30 June 2021

 

To apply:

https://emploi.cnrs.fr/Offres/CDD/UMR5297-MELDES0-059/Default.aspx?lang=EN

The Turing Centre for Living Systems (CENTURI) wishes to attract talented Postdoc candidates to the Luminy campus. To do so, CENTURI will fund up to 5 Postdoc positions to start in December 2021. Postdocs will work in an interdisciplinary life science environment, and have backgrounds in any of the following fields: cell or developmental biology, immunology, neurobiology, biophysics, theoretical physics, computer science, bioinformatics, applied mathematics, engineering.

Candidates can either apply to one of the advertised CENTURI projects or submit their own project, providing that they meet the application criteria and that their application is supported by at least 2 host labs.

Postdocs will be co-supervised by two or three supervisors from our community. Candidates can apply to a maximum of three projects.

Do not hesitate to contact the projects’ supervisors for more information.

 

Applications must be submitted via the project’s application form and must be written in English. 

 

Deadline for application: April 16, 2021

Duration: 2 years

On-site or video interviews: June 17 and June 18