Quantifying translation in space and time during development

During development, precise control of gene expression allows the reproducible establishment of patterns, leading to the formation of organs at the right time and place.

The establishment of developmental patterns has been primarily studied at the transcriptional level. In comparison, the fate of these transcripts received little attention.

Dufourt*, Bellec* et al deployed the SunTag labeling method to image the dynamics of translation of individual mRNA molecules in living Drosophila embryos. This led to the discovery of translation factories and unmasked important heterogeneities in the efficiency of translation between identical mRNAs, demonstrating a novel layer of fine-tuning of gene expression.

Imaging translation dynamics in live embryos reveals spatial heterogeneities.

Dufourt J, Bellec M, Trullo A, Dejean M, De Rossi S, Favard C, Lagha M.

Science. 29 avril 2021 doi: 10.1126/science.abc3483.

Contact:

Mounia Lagha (CNRS)

mounia.lagha@igmm.cnrs.fr

+33 434359653

twitter : drosoigmm

Institut de Génétique Moléculaire de Montpellier (Univ.Montpellier/CNRS) 1919 route de Mende, 34090 Montpellier

We are pleased to announce the 5th EMBL Course for Bioimage Data Analysis to be held from Sunday, 14 May – Saturday , 20 May 2017. The deadline for application is March 15th, 2017.

This course will focus on computational methods for analysing images of proteins, cells and tissues, to boost the learning process of participants who have an immediate need to analyze images in their own research. For this, the course extends from basic foundations of image processing and programming to the actual implementation of workflows using scripting in ImageJ macro and MATLAB languages. We aim to gather expert knowledge to organize a world-leading course for bioimage analysis in the fields of cell & developmental biology, biochemistry and biophysics. A report written by a student in 2014 could give you some idea about the course.

The course will take place in Heidelberg, Germany at the EMBL Advanced Training Centre. Registration and motivation letter deadline is March 15, 2017. Please visit our course website for more details.
We look forward to welcoming you to Heidelberg, Germany.

Scientific Organisers,
Kota Miura, University of Heidelberg, Germany, NIBB, Okazaki Japan
Sébastien Tosi, Institute for Research in Biomedicine – IRB Barcelona, Spain
Perrine Paul-Gilloteaux, CNRS SFR F. Bonamy University of Nantes, France

If you have any questions, please do not hesitate to contact:
Bronagh Carey
Administrative Organizer, BIAS 2017
Conference Officer
European Molecular Biology Laboratory