The Toulouse node is composed of a large nationally recognized multi-site core facility: Toulouse Reseau Imagerie. Distributed on Toulouse greater area, the facility is divided between medical science, fondamental science, cancer and rejuvenation, and agro-bio science. Moreover, eight R&D teams complete the node and supports the facility (from LAAS, CBI, IPBS, IRSD and IMT).

The Toulouse node aims to maintain the level of scientific excellence in response to the needs of users and the concerns of host laboratories. Four scientific axes are conducted: mechano-biology, molecules and single cells, whole organisms, image processing and quantitative data analysis. The mission of the node is also to develop original devices to explore biophysical properties in living samples, to work at the interface between machine and sample and to develop artificial intelligence applied to bioimaging.

2022 in numbers

  • 619 projects hosted
  • 77 publications
  • 18 training programs
  • 5 patents since 2011

Technological Innovations

  • Random illumination microscopy (RIM)
  • Protrusion Force Microscopy
  • Anchor technology
  • Microfabrication for organoids
  • SPIM & macroSPIM

Most innovative systems available for booking

  • Raman CARS/SRS
  • Cryo TEM & SEM
  • Spectral flow cytometry
  • Image analysis service
  • Multiphotons et spinning disk at Biosafety Level3

Tech transfer

  • Random illumination microscopy (transfert to a startup in project)
  • TauFLIM software (Photonlines)
  • Cryomethods in electron transmission microscopy
  • Light sheet microscopy (SPIM, macroSPIM)
Facility

Toulouse Reseau Imagerie (TRI)

↗ Website ↗ Service + Info

Facility: Toulouse Reseau Imagerie (TRI)

Head: Olivier GADAL

tricontact@genotoul.fr
Center for Integrative Biology, Rue Marianne Grunberg-Manago, Toulouse, France

Services on this Facility

Service

Microscopy Technologies

Facility

CRCT – Tri-Genotoul

↗ Website + Info

Facility: CRCT – Tri-Genotoul

Head: Laetitia LIGAT

laetitia.ligat@inserm.fr
2 Av. Hubert Curien, 31100 Toulouse, France
Facility

CMEAB – Tri-Genotoul

↗ Website + Info

Facility: CMEAB – Tri-Genotoul

Head: Bruno PAYRE

bruno.payre@univ-tlse3.fr
Faculté de Médecine Rangueil, 133 Route de Narbonne, Toulouse, France
Facility

FRAIB – Tri-Genotoul

↗ Website + Info

Facility: FRAIB – Tri-Genotoul

Head: Cécile POUZET

imagerie@fraib.fr
FRAIB, Chemin de Borde Rouge, Castanet-Tolosan, France
Facility

I2MC- TRI Genotoul

↗ Website + Info

Facility: I2MC- TRI Genotoul

Head: Rémy FLORES FLORES & Alexia ZAKAROFF

remy.flores-flores@inserm.fr
I2MC Inserm U1297 - Institut des maladies métaboliques et cardiovasculaires, 1 Avenue du Professeur Jean Poulhès, Toulouse, France
Facility

INFINITy – Tri-Genotoul

↗ Website + Info

Facility: INFINITy – Tri-Genotoul

Head: Sophie ALLART

sophie.allart@inserm.fr
INFINITy (Institut Toulousain des Maladies Infectieuses et Inflammatoires) INSERM U1291, Toulouse, France
Facility

IPBS – Tri-Genotoul

↗ Website + Info

Facility: IPBS – Tri-Genotoul

Head: Reanud POINCLOUX

gimagerie-adm@ipbs.fr
IPBS-Toulouse, 205 Route de Narbonne, Toulouse, France
Facility

irsd – Tri-Genotoul

↗ Website + Info

Facility: irsd – Tri-Genotoul

Head: Nathalie VERGNOLLE

nathalie.vergnolle@inserm.fr
105 Av. de Casselardit, 31300 Toulouse, France
Facility

LICT (CBI) – Tri-Genotoul

↗ Website + Info

Facility: LICT (CBI) – Tri-Genotoul

Head: Olivier GADAL

olivier.gadal@univ-tlse3.fr
IBCG buiding, Toulouse, France
Facility

METi – Tri-Genotoul

↗ Website + Info

Facility: METi – Tri-Genotoul

Head: Corinne LORENZO & Jacques ROUQUETTE

celia.plisson-chastang@univ-tlse3.fr
IBCG buiding, Toulouse, France
Facility

RESTORE – Tri-Genotoul

↗ Website + Info

Facility: RESTORE – Tri-Genotoul

Head: Corinne BARREAU

corinne.barreau@inserm.fr
4 bis Avenue Hubert Curien, Toulouse, France
R&D team

Engineering for Life Sciences and Applications (ELiA) team – LAAS

↗ Website + Info

R&D team: Engineering for Life Sciences and Applications (ELiA) team – LAAS

Head: Laurent MALAQUIN

laurent.malaquin@laas.fr
7 Avenue du Colonel Roche, Toulouse, France
R&D team

MechaBioFluidics team – LAAS

↗ Website + Info

R&D team: MechaBioFluidics team – LAAS

Head: Morgan DELARUE

aurelien.bancaud@laas.fr ; morgan.delarue@laas.fr
7 Avenue du Colonel Roche, Toulouse, France
R&D team

Chromatin and gene expression team – MCD-CBI

↗ Website + Info

R&D team: Chromatin and gene expression team – MCD-CBI

Head: Kerstin BYSTRICKY

kerstin.bystricky@univ-tlse3.fr
Université Paul Sabatier, 118 Route de Narbonne, Toulouse, France
R&D team

Phagocyte architecture and dynamics team – IPBS

↗ Website + Info

R&D team: Phagocyte architecture and dynamics team – IPBS

Head: Christel VEROLLET & Renaud POINCLOUX

christel.verollet@ipbs.fr ; renaud.poincloux@ipbs.fr
IPBS-Toulouse, Route de Narbonne, Toulouse, France
R&D team

Ribosome Synthesis and Rare Diseases team – MCD-CBI

↗ Website + Info

R&D team: Ribosome Synthesis and Rare Diseases team – MCD-CBI

Head: Pierre-Emmanuel GLEIZES

pierre-emmanuel.gleizes@univ-tlse3.fr
118 Route de Narbonne, Toulouse, France
R&D team

Gut protease signals team – IRSD

↗ Website + Info

R&D team: Gut protease signals team – IRSD

Head: Nathalie VERGNOLLE

nathalie.vergnolle@inserm.fr
105 Av. de Casselardit, 31300 Toulouse, France
R&D team

Super-resolution imaging team – LITC

↗ Website + Info

R&D team: Super-resolution imaging team – LITC

Head: Thomas MANGEAT

thomas.mangeat@univ-tlse3.fr
118 Route de Narbonne, Toulouse, France
R&D team

MAthématiques pour l’iMagerie BiOlogique (MAMBO) team – MCD-CBI

↗ Website + Info

R&D team: MAthématiques pour l’iMagerie BiOlogique (MAMBO) team – MCD-CBI

Head: Pierre WEISS

pierre.weiss@cnrs.fr
Centre de Biologie Intégrative (CBI), Rue Marianne Grunberg-Manago, Toulouse, France
R&D team

Oncorib Ribosomes in Normal and Pathological Conditions team – CBI

↗ Website + Info

R&D team: Oncorib Ribosomes in Normal and Pathological Conditions team – CBI

Head: Celia PLISSON-CHASTANG

celia.plisson-chastang@utoulouse.fr
Centre de Biologie Intégrative (CBI), Rue Marianne Grunberg-Manago, Toulouse, France

Key publications

  • Assia Asrir, Claire Tardiveau, Juliette Coudert, Robin Laffont, Lucas Blanchard, et al.. Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD1 plus CTLA-4 combination immunotherapy. Cancer Cell, In press, 17 p. ff10.1016/j.ccell.2022.01.002ff. ffhal-03576428f
  • Marion Jasnin, Jordan Hervy, Stéphanie Balor, Anaïs Bouissou, Amsha Proag, et al.. Elasticity of podosome actin networks produces nanonewton protrusive forces. Nature Communications, 2022, 13 (1), pp.3842. ff10.1038/s41467-022-30652-6ff. ffhal-03817191
  • Portes M, Mangeat T, Escallier N, Dufrancais O, Raynaud-Messina B, Thibault C, Maridonneau-Parini I, Vérollet C, Poincloux R. Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts. Elife. 2022 Jun 21;11:e
  • Record M, Attia M, Carayon K, Pucheu L, Bunay J, Soulès R, Ayadi S, Payré B, Perrin-Cocon L, Bourgailh F, Lamazière A, Lotteau V, Poirot M, Silvente-Poirot S, de Medina P. Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles. J Extracell Vesicles. 2022 Apr;11(4):e12211. doi: 10.1002/jev2.12211. PMID: 35411723; PMCID: PMC9001168
  • Marie-Françoise O’Donohue, Lydie Da Costa, Marco Lezzerini, Sule Unal, et al.. HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia, Blood, Volume 139, Issue 21, 2022, Pages 3111-3126, ISSN 0006-4971,