Postdoc in Spatiotemporal organization of mRNA nuclear biogenesis, from chromatin to the nuclear pore complex
Organization: Inserm, IUH Hôpital St Louis, Paris X, France
Position Information:
While most of the molecular actors involved in the biogenesis and export of
messenger ribonucleoparticles (mRNPs) have been characterized, their molecular
interplay, the spatiotemporal organization of these processes as well as their intricate
relation with chromatin dynamics remains elusive. We recently reported that histone
marks as well as chromatin remodelers could impact mRNP biogenesis
independently of the transcription process per se. We now aim at deepening our
understanding of these fundamental questions. This will be addressed in the model
organism S. cerevisiae using a combination of approaches including genetics,
molecular biology (ChIP, RNA-IP,CRAC,RNAseq) and microscopy (live-cell imaging).