Bioorganic Chemistry team (15 people) develops bioconjugation, surface modification, multi-step synthesis, to create biocompatible chemical tools to explore the complexity of living mechanisms. The team’s expertise ranges from organic synthesis to photophysics; aiming at the development and tailoring of 1) new organic fluorophores (either push-pull or ESIPT based with high Stokes shifts and solvatochromism), with a recognized know-how in cyanins, coumarins, rhodamins, indazoles or BODIPY fluorescent scaffolds, notably their NIR derivatives, for application in conventional, two photon and STED microscopy, 2) biodetection (proteins, DNA) techniques based on profluorescent or chemiluminescent probes, and 3) new chemobiology tools such as bioconjugation reactions (and click-chemistry type tools), chemical or photoreactive cross-linkers, photolabile groups. The team collaborates with industrial companies through Carnot I2C and with international collaborators through XL-Chem program.