MicroPICell (Tissue and cell imaging)
Type: Facility
Business services: Yes
Head title: Head
Head name: Perrine PAUL-GUILLOTEAUX, Vincent GUEN
Contact: perrine.paul-gilloteaux@univ-nantes.fr & micropicell@univ-nantes.fr
Website Service: https://micropicell.univ-nantes.fr/equipement-1066521.kjsp?RH=1386769682457&RF=1386769682457
Node: Bretagne-Loire
Location: 8 Quai Moncousu, 44000 Nantes, France
Available service offers on this site
The automation of fluorescence microscopy represents a challenge for the study of rare or transient events in biology and medicine. It relies on intelligent devices that integrate and interpret observed…
Development, observation and identification of specific markers on 3D models and tissue
support from sample preparation to image analysis - including visualisation of organoids/spheroids in 3D imaging. Pool of systems and expertise for these studies (transparization, staining, light sheets, etc.).
High temporal resolution, particularly for ionic flows
Measuring Ca²⁺ or pH in microscopy is important because both are fundamental regulators of cellular activity. Calcium controls processes such as signaling, contraction, and secretion, while pH influences enzyme activity,…
High throughput slide production, staining and digitisation services
Our 2 platforms offer routine services in histology, tissue processing, thin sections, staining, immunohistochemistry and digitisation of microscopy slides (Hamamtsu S360 & S60 scanners).
Image analysis (training/contracting)
Python, ImageJ, Fiji, QuPath,plugin, macro, notebook, deep-learning and many others
Kratoscope (system based on autofluorescence or labelling installed on microtome or cryostat for 3D imaging and recovery of sections)
the imaging system Kratoscope acquires an image of the organ in the block of tissue each time a slice is cut by a microtome (FFPE blocks) or a cryostat (frozen…
LIPSI (robotised confocal HCS and HTS, with Smart microscopy capability)
High content microscopy with Nikon’s confocal LIPSI system combines automated image acquisition with integrated analysis, making it particularly powerful for high-content screening and live-cell studies. By reducing manual steps such…
Multimodal correlative microscopy, including CLEM
Multimodal microscopy, by combining fluorescence, harmonic and electron microscopy signals, is therefore of real interest for taking advantage of complementary information and increasing the sensitivity of pathology detection to qualify…
Multiplex imaging
makes it possible to observe a large number of biomarkers simultaneously and to identify the diversity of cell populations and their interactions within a sample. Immunofluorescence imaging offers high spatial…
Spatial super resolution (Airy Scan, NSIM, RIM, NSpark, STORM Abbelight)
spatial super resolution by ISM (Image Scanning Microscopy) with AiryScan and NSpark in confocal (Zeiss and Nikon); by structured illumination with NSIM and RIM (Nikon and prototype); by SMLM with…
Unlabelled cellular or tissue imaging: SHG, autofluorescence (kratoscope), Raman, holotomography
Unlabelled imaging can be used to characterise histological sections by mapping them without treatment. It is also possible to complete the analysis using immunohistochemistry, multiplex immunoflorescence or histological staining technologies.…