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MicroPICell (Tissue and cell imaging)

Type: Facility

Business services: Yes

Head title: Head

Head name: Perrine PAUL-GUILLOTEAUX, Vincent GUEN

Contact: perrine.paul-gilloteaux@univ-nantes.fr & micropicell@univ-nantes.fr

Website: https://micropicell.univ-nantes.fr/bienvenue-sur-micropicell-1047136.kjsp?RH=1542712634037&RF=1298884610558

Website Service: https://micropicell.univ-nantes.fr/equipement-1066521.kjsp?RH=1386769682457&RF=1386769682457

Node: Bretagne-Loire

Location: 8 Quai Moncousu, 44000 Nantes, France

Available service offers on this site

Development of complex acquisitions (smart Microscopy)

The automation of fluorescence microscopy represents a challenge for the study of rare or transient events in biology and medicine. It relies on intelligent devices that integrate and interpret observed…
Smart microscopy

Development, observation and identification of specific markers on 3D models and tissue

support from sample preparation to image analysis - including visualisation of organoids/spheroids in 3D imaging. Pool of systems and expertise for these studies (transparization, staining, light sheets, etc.).
3D imaging

High temporal resolution, particularly for ionic flows

Measuring Ca²⁺ or pH in microscopy is important because both are fundamental regulators of cellular activity. Calcium controls processes such as signaling, contraction, and secretion, while pH influences enzyme activity,…
Intravital microscopy

High throughput slide production, staining and digitisation services

Our 2 platforms offer routine services in histology, tissue processing, thin sections, staining, immunohistochemistry and digitisation of microscopy slides (Hamamtsu S360 & S60 scanners).
Smart microscopy

Image analysis (training/contracting)

Python, ImageJ, Fiji, QuPath,plugin, macro, notebook, deep-learning and many others
Image analysis

Kratoscope (system based on autofluorescence or labelling installed on microtome or cryostat for 3D imaging and recovery of sections)

the imaging system Kratoscope acquires an image of the organ in the block of tissue each time a slice is cut by a microtome (FFPE blocks) or a cryostat (frozen…
3D imaging

LIPSI (robotised confocal HCS and HTS, with Smart microscopy capability)

High content microscopy with Nikon’s confocal LIPSI system combines automated image acquisition with integrated analysis, making it particularly powerful for high-content screening and live-cell studies. By reducing manual steps such…
Smart microscopy

Multimodal correlative microscopy, including CLEM

Multimodal microscopy, by combining fluorescence, harmonic and electron microscopy signals, is therefore of real interest for taking advantage of complementary information and increasing the sensitivity of pathology detection to qualify…
Electron microscopy

Multiplex imaging

makes it possible to observe a large number of biomarkers simultaneously and to identify the diversity of cell populations and their interactions within a sample. Immunofluorescence imaging offers high spatial…
Multiplex imaging and cytometry

Spatial super resolution (Airy Scan, NSIM, RIM, NSpark, STORM Abbelight)

spatial super resolution by ISM (Image Scanning Microscopy) with AiryScan and NSpark in confocal (Zeiss and Nikon); by structured illumination with NSIM and RIM (Nikon and prototype); by SMLM with…
Super-resolution microscopy

Unlabelled cellular or tissue imaging: SHG, autofluorescence (kratoscope), Raman, holotomography

Unlabelled imaging can be used to characterise histological sections by mapping them without treatment. It is also possible to complete the analysis using immunohistochemistry, multiplex immunoflorescence or histological staining technologies.…
Label-free imaging