Service
7 imaging facilities and 17 R&D teams
The Paris-Centre node gathers biological imaging resources in the center of Paris, associating 7 imaging facilities and 17 R&D teams. The node Paris-Centre has the objective to make new developments and implementations of state of the art imaging systems, chemical probes and image processing for single molecules localization, dynamics and interactions in live cells, tissues and organisms and to perform cell functional analysis by using opto-manipulation. Paris Centre node was deeply involved in the “proof of concept” study led by the EurobioImaging ESFRI project.
Technological Innovations
- Computational tools & approaches (PNAS 2014, Nat Meth 2012, 2015)
- 3D multi-focus multicolor PALM (PNAS, PCCP 2014)
- Multimodal microscopy (Super-CLEM; FLCS; STED-Holographic photoactivation) (Nature 2015, Meth Biol, 2014)
- Holographic photoactivation (Neuron, 2014)
- Ultrafast & deep 2P-microscopy (Opt Exp, 2015)
- Photoswitchable probe (PNAS, 2016)
Most innovative systems available for booking
- 3D-MFM multicolor PALM
- 3D Multi-Angles TIRFM Multicolor
- 3D PALM/STORM
- Patterned microendoscope
Tech transfer
- Live SR Microscope (Roper Scientific)
- Digital holographic temporal focusing (3i)
Facility
UTechS UBI – Institut Pasteur
Facility
PICT – Institut Curie
Facility: PICT – Institut Curie
Head: Vincent FRAISIER - Patricia LE BACCON (PICT-Light Microscopy) & Daniel LEVY (PICT-Electron Microscopy)
Info.pict@curie.fr
Institut Curie, Rue d'Ulm, Paris, France
Services on this Facility
Service
HCS & HTP facilities
Service
Image Data Handling
Service
Microscopy Technologies
Facility
ImaChem – IBENS
Facility
UTechS PBI – Institut Pasteur
Facility
Imagoseine – Institut Jacques Monod
Facility
IMAG’IC – Institut Cochin photonic imaging facility
Facility
NeurImag – IPNP
Facility
ImaChem – Collège de France
R&D team
Physical and Biological Chemistry of Living Matter team – ENS Chemistry
R&D team
Complex Media Optics team – Laboratory Kastler-Brossel
R&D team
Dynamic Control of Signaling and Gene Expression team – Institut Curie
R&D team
Biology of Phagocytes, Infection and Immunity team – Institut Cochin
R&D team
Molecular Motors and Machines team – IBENS
R&D team
Imaging and Modeling team – Institut Pasteur
R&D team
Light-based Observation and Control of Cellular Organization team – Institut Curie
R&D team
Molecular Microscopy of Membranes team – Institut Curie
R&D team
Structure and Membrane Compartments team – Institut Curie
R&D team
Mechanotransduction: from Cell Surface to Nucleus team – Institut Jacques Monod
R&D team
Membrane Dynamics and Intracellular Trafficking team – Institut Jacques Monod
R&D team
Cell Polarity in Development and Evolution – Institut Jacques Monod
R&D team
Glutamate Receptors and Excitatory Synapses team – IBENS
R&D team
Cortical dynamics and coding mechanisms team – IBENS
Key publications
- The sacral autonomic outflow is sympathetic. I. Espinosa-Medina1,*, O. Saha1,*, F. Boismoreau1, Z. Chettouh1, F. Rossi1, W. D. Richardson2, J.-F. Brunet1. Science 18 Nov 2016: Vol. 354, Issue 6314, pp. 893-897.
- Screening out irrelevant cell-based models of disease. Horvath P1,2, Aulner N3,2, Bickle M4,2, Davies AM5,2, Nery ED6,2, Ebner D7,2, Montoya MC8,2, Östling P9,10,2, Pietiäinen V9,2, Price LS11,2, Shorte SL3,2, Turcatti G12,2, von Schantz C9,2, Carragher NO13,2. Nat Rev Drug Discov. 2016 Nov;15(11):751-769. doi: 10.1038/nrd.2016.175. Epub 2016 Sep 12.
- Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer. Casiraghi M1, Damian M2, Lescop E3, Point E1, Moncoq K1, Morellet N3, Levy D4,5,6, Marie J2, Guittet E3, Banères JL2, Catoire LJ1. J Am Chem Soc. 2016 Sep 7;138(35):11170-5. doi: 10.1021/jacs.6b04432. Epub 2016 Aug 24.